Nasa has warned the crew of space shuttle Discovery to expect rain delays as they prepare to return to Earth after their visit to the space station, BBC reported.
Discovery and its crew of seven are due to land at Florida's Kennedy Space Center on Monday.
In the worst case, the shuttle could always aim for a back-up landing site in southern California on Tuesday.
Discovery has spent two weeks at the space station stockpiling it with supplies, experiments and spare parts.
The shuttle's first opportunity to return to Earth would see Discovery fire its engines at 1143 GMT (0743 EDT) ahead of a landing at 1248 GMT (0848 EDT).
For the first time since 2007, the shuttle will cross North America, from Vancouver to Florida, giving observers on the ground an opportunity to see the vehicle as an orange streak against the sky and to hear its sonic boom.
This landing pattern, called a "descending node", has not been used since 2007.
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